Article

Effects of ABCB1 polymorphisms on the transport of ponatinib into the cerebrospinal fluid in Japanese Philadelphia chromosome-positive acute lymphoblastic leukaemia patients

2022-10-28

Abstract excerpt

The effects of polymorphisms of ABCB1 and ABCG2 on the dose-adjusted plasma trough concentrations and cerebrospinal fluid (CSF)-to-plasma ratios of ponatinib were evaluated. Blood (C4) and CSF (CSF4) concentrations at 4 h after administration were determined. The median (95% confidence interval (CI)) CSF4-to-C4 ratio of ponatinib in subjects homozygous for ABCB1 variants 1236T/T, 2677T/T+T/A, or 3435T/T were signi...

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Literature Corpus work: bac77784-ad78-53ad-8fbc-3178aeb6b7e3
DOI: 10.22541/au.166696023.32428825/v1

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