Article

Diet Modifies Colonic Microbiota and CD4 <sup>+</sup> T Cell Repertoire to Trigger Flares in a Novel Model of Colitis Induced by IL-23

2018-02-08

Abstract excerpt

A wealth of experimental data points to immunological and environmental factors in the pathogenesis of inflammatory bowel disease (IBD). Here we study the role of IL-23, the microbiome, and the diet in the development of colitis. To promote IL-23 expression in vivo, we generated a mouse model in which IL-23 was conditionally expressed by CX 3 CR1 + myeloid cells, upon cyclic administration of tamoxifen in a spec...

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Literature Corpus work: ba100951-804a-570c-8f32-9275c9f63cd3
DOI: 10.1101/262634

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