Article

SignalGen: A Protein Language Model Based AI Agent For Optimal Signal Peptide Prediction

2025-11-12

Abstract excerpt

Signal peptides are short amino acid sequences attached to the N-termini of mature proteins. They play determinant roles in protein expression as well as localization of mature proteins. While sequence-based machine learning (ML) models have been developed to identify the signal peptide sequences given the full or mature protein sequences, no model has been created to design optimal signal peptides with the locali...

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Literature Corpus work: b8a56abe-2320-5f0a-a347-9241e33b7fc4
DOI: 10.1101/2025.11.12.688111

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