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The Aspergillus fumigatus growth determinant Afu6g07200 is the first granulin described in fungi

2026-03-23

Abstract excerpt

<title>Abstract</title> <p>The Granulin motif is an ancient extracellular growth determinant in eukaryotes but not in fungi. The motif consists of 12 cysteines that give the protein a unique tertiary structure of four stacked β-hairpins. In humans, this domain is related to survival, growth modulation, migration, inflammation, wound repair, and diseases like frontotemporal dementia, Alzheimer's disease, and cance...

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Literature Corpus work: b85403cc-e133-5f7e-a56f-7c69a6175fa5
DOI: 10.21203/rs.3.rs-9044607/v1

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