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Association between PPAR-γ (rs1801282) polymorphism and susceptibility to obesity and type 2 diabetes mellitus: a meta-analysis with trial sequential analysis

2026-04-14

Abstract excerpt

<title>Abstract</title> <p> Background peroxisome proliferator-activated receptor-γ (PPAR-γ) plays a pivotal role in lipid homeostasis and insulin signaling; however, the association of its PPAR-γ rs1801282 polymorphism with obesity and type 2 diabetes mellitus (T2DM) remains controversial. Methods We searched PubMed, Web of Science, CNKI and WanFang up to September 2025. Meta-analysis was conducted across fiv...

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Literature Corpus work
b610202a-acf0-5911-bdd0-75cad1d249a9
DOI
10.21203/rs.3.rs-9008547/v1
Open publication

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