Article

McSplicer: a probabilistic model for estimating splice site usage from RNA-seq data

2020-08-11

Abstract excerpt

Alternative splicing removes intronic sequences from transcripts in alternative ways to produce different forms (isoforms) of mature mRNA. The composition of expressed transcripts and their alternative forms give specific functionalities to cells in a particular condition or developmental stage. In addition, a large fraction of human disease mutations affect splicing and lead to aberrant mRNA and protein products....

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Literature Corpus work: b4880fce-e506-59e7-81af-17b7e7bf70ad
DOI: 10.1101/2020.08.10.243097

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