Back to search

Article

In silico characterization of a putative target reveals a TssM deubiquitinase ortholog as a primary immune-evasion effector in melioidosis caused by Burkholderia pseudomallei CM000113

2026-08-21

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> <italic>Burkholderia pseudomallei</italic> , the cause of melioidosis, has a large and complex genome that contains many uncharacterized proteins. Understanding the roles of these proteins is crucial for discovering new virulence mechanisms and treatment targets. The clinical isolate <italic>B. pseudomallei</italic> CM000113 contains 3,094 uncharacterized...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b3374a65-f2bd-564f-9d27-9620c198fae1
DOI
10.21203/rs.3.rs-10572509/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
In silico characterization of a putative target reveals a TssM deubiquitinase ortholog as a primary immune-evasion effector in melioidosis caused by Burkholderia pseudomallei CM000113DOI 10.21203/rs.3.rs-10572509/v1
In silico genome-scale analysis reveals a putative TssM-like deubiquitinase as a virulence-associated marker in Burkholderia pseudomallei strain CM000113Semantic proximity
In Silico Functional Annotation of Hypothetical Proteins from Burkholderia pseudomallei strain GTC3P0254TSemantic proximity
Prediction of <i>Burkholderia pseudomallei</i> DsbA substrates identifies potential virulence factors and vaccine targetsSemantic proximity
In silico designing of a multi-epitope vaccine against Burkholderia pseudomallei: reverse vaccinology and immunoinformaticsSemantic proximity
Identification of CD4+ T-cell epitope and investigation of HLA distribution for the immunogenic proteins of Burkholderia pseudomallei using in silico approaches - A key vaccine development strategy for melioidosis.Semantic proximity
Virulence of the Melioidosis Pathogen Burkholderia pseudomallei Requires the Oxidoreductase Membrane Protein DsbBSemantic proximity
Clinicogenomic Insights into Burkholderia pseudomallei Reveal Functional Variants Associated with Clinical Outcomes in BangladeshSemantic proximity
From crystal structure to <i>in silico</i> epitope discovery in the <i>Burkholderia pseudomallei</i> flagellar hook‐associated protein FlgKSemantic proximity
Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243.Semantic proximity
Design of a Multi-epitope Vaccine Against Human Glanders Targeting Outer Membrane β-barrel Proteins of <i>Burkholderia mallei</i>Semantic proximity
Hijacking of the Host’s Immune Surveillance Radars by Burkholderia pseudomalleiSemantic proximity
Immunoinformatics and System Biology Approaches for Potential Vaccine Candidates Against Burkholderia PseudomalleiSemantic proximity
Select a neighboring publication to make it the new centre.