Article

Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy and the host’s genotype upon microbiome composition

2019-03-08

Abstract excerpt

<h4>ABSTRACT</h4> Diverse evidence including clinical, genetic and microbiome studies support a major role of the gut microbiome in the common immune-mediated arthropathy, ankylosing spondylitis (AS). To further investigate this we performed metagenomic analysis of a case-control cohort of 250 Han-Chinese subjects. Previous reports of gut dysbiosis in AS were re-confirmed and several notable bacterial species and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b22f87d4-32fe-575f-a970-197b1c8a4d58
DOI: 10.1101/571430

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy and the host’s genotype upon microbiome compositionDOI 10.1101/571430Read

Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome compositionSemantic proximity Read

Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitisSemantic proximity Read

The gut microbiome and HLA-B27-associated anterior uveitis: a case-control studySemantic proximity Read

HLA risk alleles and gut microbiome in ankylosing spondylitis and rheumatoid arthritis.Semantic proximity Read

Both Disease Activity and HLA–B27 Status Are Associated With Gut Microbiome Dysbiosis in Spondyloarthritis PatientsSemantic proximity Read

Variations in gut microbial profiles in ankylosing spondylitis: disease phenotype-related dysbiosisSemantic proximity Read

Characteristics of the intestinal microbiome in ankylosing spondylitisSemantic proximity Read

HLA alleles associated with risk of ankylosing spondylitis and rheumatoid arthritis influence the gut microbiomeSemantic proximity Read

Genetics of Ankylosing Spondylitis—Focusing on the Ethnic Difference Between East Asia and EuropeSemantic proximity Read

<scp>HLA</scp> Alleles Associated With Risk of Ankylosing Spondylitis and Rheumatoid Arthritis Influence the Gut MicrobiomeSemantic proximity Read

The microbiome and autoimmunity: a paradigm from the gut–liver axisSemantic proximity Read

Gut microbiota-microRNA interactions in ankylosing spondylitis.Semantic proximity Read