Article

Targeting Lyn Kinase in Chorea-Acanthocytosis: A Translational Treatment Approach in an Ultra-Rare Disease

2021-03-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chorea-acanthocytosis (ChAc) is a neurodegenerative disease caused by mutations in the VPS13A gene. It is characterized by several neurological symptoms and the appearance of acanthocytes. Elevated tyrosine kinase Lyn activity has been recently identified as one of the key pathophysiological mechanisms and therefore represents a promising drug target. <h4>Methods</h4> We evalu...

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Literature Corpus work: b1d265d2-b287-5316-bd30-3c4bd2bd5646
DOI: 10.1101/2021.03.08.21252937

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