Article

A Timeline of Symptom Onset and Disease Progression in CLN3 Disease

2025-09-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> CLN3 disease, or Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), is a rare, genetic neurodegenerative condition, typically manifesting in the first decade of life and progressing in severity, with death typically occurring in early adulthood. Despite two decades of natural history research, a clear timeline of CLN3 disease symptom onset and progression remains poorly defined...

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Literature Corpus work: f0d239c5-ed5c-5e7f-bd53-4b695313493c
DOI: 10.1101/2025.08.31.25334748

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