Article

Endo180 and basement membrane stiffness induce OXPHOS and neoplasia in aging prostate epithelia

2024-09-19

Abstract excerpt

<title>Abstract</title> <p>During prostate aging collagen-IV is modified by advanced glycation end-products (AGEs), inducing crosslinking of the basement membrane that surround glandular acini. AGEs-rich (stiff) basement membrane is sensed by the Endo180 receptor that triggers epithelial-to-mesenchymal transition, limiting survival in prostate cancer patients. Our finding that basement membrane stiffness and Endo...

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Literature Corpus work: b0f1db8e-21a0-538b-9089-089a1d903b08
DOI: 10.21203/rs.3.rs-4837876/v1

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