Article

NR4A1 Modulates Glioblastoma Sensitive to Erastin-Induced Ferroptosis via NCOA4 mediated Autophagy

2025-12-22

Abstract excerpt

<title>Abstract</title> <p> Autophagy-mediated ferritin degradation (ferritinophagy) is recognized as a critical driver of ferroptosis; however, the molecular circuitry linking selective autophagy to ferroptosis in glioma remains incompletely defined. Here, we demonstrate that the orphan nuclear receptor NR4A1 as an essential orchestrator of autophagy initiation during ferroptosis. Analysis of TCGA data revealed...

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Literature Corpus work: b0a5fbfd-d3b3-581f-af31-0391223d8569
DOI: 10.21203/rs.3.rs-8304233/v1

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