Article

Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses

2020-04-25

Abstract excerpt

Multi-omics datasets can provide molecular insights beyond the sum of individual omics. Diverse tools have been recently developed to integrate such datasets, but there are limited strategies to systematically extract mechanistic hypotheses from them. Here, we present COSMOS (Causal Oriented Search of Multi-Omics Space), a method that integrates phosphoproteomics, transcriptomics, and metabolics datasets. COSMOS c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b01b6191-8434-51fa-a662-21fddc42eb2a
DOI: 10.1101/2020.04.23.057893

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Causal integration of multi-omics data with prior knowledge to generate mechanistic hypothesesDOI 10.1101/2020.04.23.057893Read

Modeling causal signal propagation in multi-omic factor space with COSMOSSemantic proximity Read

SignalingProfiler 2.0 a network-based approach to bridge multi-omics data to phenotypic hallmarks.Semantic proximity Read

MOPA: An integrative multi-omics pathway analysis method for measuring omics activitySemantic proximity Read

<i>SignalingProfiler</i> 2.0: a network-based approach to bridge multi-omics data to phenotypic hallmarksSemantic proximity Read

GraphOmics: An Interactive Platform To Explore And Integrate Multi-Omics DataSemantic proximity Read

PIMO: Pathway-based Interpretable Multi-Omics interactions for multi-omics integrationSemantic proximity Read

TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics dataSemantic proximity Read

Directional integration and pathway enrichment analysis for multi-omics dataSemantic proximity Read

Lemonite: identification of regulatory metabolites through data-driven, interpretable integration of transcriptomics and metabolomics dataSemantic proximity Read

MPAC: a computational framework for inferring pathway activities from multi-omic dataSemantic proximity Read

AutoMRAI: A Multi-Omics Causal Inference Platform Using Structural Equation ModellingSemantic proximity Read

OmniPath Metabo: chemical structures, interactions and mechanisms to study the metabolomeSemantic proximity Read