Back to search

Article

Identification of saquinavir as a potent inhibitor of dimeric SARS-CoV2 main protease through MM/GBSA

2020-05-12

Abstract excerpt

Among targets selected for studies aimed to identify potential inhibitors against COVID-19, SARS-CoV2 main proteinase (M pro ) is highlighted. M pro is indispensable for virus replication, and is a promising target of potential inhibitors of COVID-19. Recently, monomeric SARS-CoV2 M pro , drug repurposing and docking methods have facilitated the identification of several potential inhibitors. Results were refined...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b003b1aa-70c8-50f4-bd5a-a24481211266
DOI
10.21203/rs.3.rs-27406/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of saquinavir as a potent inhibitor of dimeric SARS-CoV2 main protease through MM/GBSADOI 10.21203/rs.3.rs-27406/v1
Interaction of Drug Candidates with Various SARS-CoV‑2 Receptors: An in Silico Study to Combat COVID-19Semantic proximity
Genetic Algorithm-Based Docking of Potent Inhibitors Against SARS-CoV-2 Main Protease: A Comparison Between Natural Products and Synthetic Drugs.Semantic proximity
Old Arsenal to Combat New Enemy: Repurposing of Commercially Available FDA Approved Drugs Against Main Protease of SARS-CoV2.Semantic proximity
Predicting Antiviral Resistance Mutations in SARS-CoV-2 Main Protease with Computational and Experimental Screening.Semantic proximity
Drug Repurposing of Allophenylnorstatine Containing HIV-Protease Inhibitors Against SARS-CoV-2 Mpro: Insights from Molecular Dynamics Simulations and Binding Free Energy EstimationsSemantic proximity
ABBV-744 and Onalespid as Potential Inhibitors of SARS-CoV-2 main Protease Enzyme: A Promising Therapeutics in COVID-19?Semantic proximity
Structure-Based Virtual Screening to Discover Potential Lead Molecules for the SARS-CoV‑2 Main ProteaseSemantic proximity
Integrated Docking and Enhanced Sampling Based Selection of Repurposing Drugs for SARS-CoV-2 by Targeting Host Dependent FactorsSemantic proximity
In Silico Elucidation of Potent Inhibitors and Rational Drug Design against SARS-CoV-2 Papain-like ProteaseSemantic proximity
Structural Differences In 3C-like protease (Mpro) From SARS-CoV and SARS-CoV-2: Molecular Insights For Drug Repurposing Against COVID-19 Revealed by Molecular Dynamics SimulationsSemantic proximity
Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative StudySemantic proximity
Natural compounds as potential inhibitors of novel coronavirus (COVID-19) main protease: An in silico studySemantic proximity
Select a neighboring publication to make it the new centre.