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Design and synthesis of novel EGFR kinase inhibitors for the treatment of EGFR C797S mutation in non-small cell lung cancer

2024-04-29

Abstract excerpt

<title>Abstract</title> <p>Third-generation cutaneous growth factor receptor tyrosine kinase inhibitors have led to impressive advances in the treatment of non-small cell lung cancer. However, acquired resistance significantly limits the clinical application of these agents, with the epidermal growth factor receptor (EGFR)<sup>C797S</sup> mutation being the primary resistance mechanism. In this study, a series of...

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Literature Corpus work
94a36230-6961-5bca-a5d1-95428e963b1e
DOI
10.21203/rs.3.rs-4278759/v1
Open publication

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