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Article

Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth.

Cell communication and signaling : CCS - 5 Dec 2024

Zhou Rui, Liu Ziqian, Wu Tongtong, Pan Xianwei, Li Tongtong, Miao Kaiting, Li Yuru, Hu Xiaohui, Wu Haigang, Hemmings Andrew M, Jiang Beier, Zhang Zhenzhen, Liu Ning

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) T790M mutation often occurs during long durational erlotinib treatment of non-small cell lung cancer (NSCLC) patients, leading to drug resistance and disease progression. Identification of new selective EGFR-T790M inhibitors has proven challenging through traditional screening platforms. With great advances in computer algorithms, machine learning improved the...

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Identifiers

PMID: 39639305
DOI: 10.1186/s12964-024-01954-7
PMCID: PMC11619116

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