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Article

Identification and characterization of a SARS-CoV-2 Mpro G23 deletion ensitrelvir-resistant mutant.

mBio - 8 Jul 2026

Ma Yao, Ye Chengjin, Rahisuddin R, Mahmoud Sara H, Cupic Anastasija, Khalil Ahmed Magdy, Castro Esteban, Jackson Nathaniel, Bayoumi Mahmoud, Arya Shailee, Gupta Yogesh K, García-Sastre Adolfo, Plemper Richard K, Martinez-Sobrido Luis

Abstract excerpt

Ensitrelvir is an antiviral drug that specifically targets the conserved main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, mutations in Mpro could confer resistance to antivirals, including ensitrelvir. Thus, identifying SARS-CoV-2 drug-resistant mutants and elucidating their mechanisms of resistance are critical for guiding the selection of effective antiviral...

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Coronavirus 3C Proteases
Indazoles
Lactams
Leucine
Sulfonic Acids

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PMID: 42233671
DOI: 10.1128/mbio.00584-26
PMCID: PMC13343909

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