Article

Transcript imbalance from TENM4 exon skipping: effects on epilepsy and genetic pleiotropy

2025-08-27

Abstract excerpt

<title>Abstract</title> <p> TENM4 is a transmembrane protein belonging to the teneurin family. It is localized in neurons and oligodendrocytes, where it regulates oligodendrocytes maturation and myelination. While missense variants of <italic>TENM4</italic> were reported to cause essential tremor and schizophrenia, we identified a novel variant of uncertain significance at exon 10-intron 10 junction, c.1255 +...

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Literature Corpus work: ad0cc198-c9cd-58f1-840c-dd1ef1c5490a
DOI: 10.21203/rs.3.rs-7261185/v1

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