Article

SARS-CoV-2 Mpro protease as a biomarker and therapeutic target in Long COVID: a real-world prospective cohort study

2026-02-19

Abstract excerpt

<title>Abstract</title> <p> Long COVID affects 400 million people worldwide, for whom predictive biomarkers and effective therapies are urgently needed. Herein, we investigate SARS-CoV-2 viral RNAs as candidate biomarkers and therapeutic targets. Combining whole blood digital transcriptomics and plasma proteomics, viral RNAs significantly correlated with platelet-expressed genes/proteins and complement/coagulati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac82d76f-c97f-53b6-9f04-95e3f89e05a5
DOI: 10.21203/rs.3.rs-7449833/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 Mpro protease as a biomarker and therapeutic target in Long COVID: a real-world prospective cohort studyDOI 10.21203/rs.3.rs-7449833/v1Read

Blood transcriptomics reveal persistent SARS-CoV-2 RNA and candidate biomarkers in Long COVID patientsSemantic proximity Read

Blood transcriptomic analyses reveal persistent SARS-CoV-2 RNA and candidate biomarkers in post-COVID-19 conditionSemantic proximity Read

Proteome reveals antiviral host response and NETosis during acute COVID-19 in high-risk patientsSemantic proximity Read

Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID.Semantic proximity Read

High-Density Blood Transcriptomics Reveals Precision Immune Signatures of SARS-CoV-2 Infection in Hospitalized IndividualsSemantic proximity Read

Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approachesSemantic proximity Read

Plasma Proteome of Long-covid Patients Indicates Hypoxia-mediated Vasculo-proliferative Disease With Impact on Brain and Heart FunctionSemantic proximity Read

Integrated analysis of bulk multi omic and single-cell sequencing data confirms the molecular origin of hemodynamic changes in Covid-19 infection explaining coagulopathy and higher geriatric mortalitySemantic proximity Read

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSemantic proximity Read

Precise blood proteome profiling in an undiagnosed population with COVID-19Semantic proximity Read

Identification of soluble biomarkers that associate with distinct manifestations of long COVIDSemantic proximity Read

SARS-CoV-2 putative mi-RNAs may target host immune system and cellular mechanisms to mediate pathogenesis-an in silico and in vivo studySemantic proximity Read