Article

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

2020-06-16

Abstract excerpt

<h4>Objectives</h4> Two of the main target tissues of SARS-coronavirus 2 are the oral cavity pharynx-larynx epithelium, the main virus entry site, and the lung epithelium. The virus enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. Herein we aim to assess differences in both ACE2 and TMPRSS2 expression in normal tissues from oral cavity-phary...

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Literature Corpus work: ac3b83fb-e449-50a0-b8f3-cb6a5923fda0
DOI: 10.1101/2020.06.16.154211

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