Article

Uncertainty in RNA-seq gene expression data

2018-10-17

Abstract excerpt

RNA-sequencing data is widely used to identify disease biomarkers and therapeutic targets. Here, using data from five RNA-seq processing pipelines applied to 6,690 human tumor and normal tissues, we show that for >12% of protein-coding genes, in at least 1% of samples, current best-in-class RNA-seq processing pipelines differ in their abundance estimates by more than four-fold using the same samples and the same...

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Literature Corpus work: abd273d0-58e1-53bb-b7ce-953d5ab77b1c
DOI: 10.1101/445601

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