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A scoping review identified additional considerations for defining estimands in cluster randomised trials

2025-06-26

Abstract excerpt

<h4>Background and objective</h4> An estimand is a clear description of the treatment effect a study aims to quantify. The ICH E9(R1) addendum lists five attributes that should be described when defining an estimand. However, the addendum was primarily developed for individually randomised trials. Cluster randomised trials (CRTs), in which groups of individuals are randomised, have additional considerations for de...

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Literature Corpus work
ab80747b-140a-5361-94c5-787375ac4f66
DOI
10.1101/2025.06.25.25330127
Open publication

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A scoping review identified additional considerations for defining estimands in cluster randomised trialsDOI 10.1101/2025.06.25.25330127
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