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Development of a consensus extension of the estimands framework for cluster randomised trials (CRT-estimands): results from an international Delphi study

2025-07-03

Abstract excerpt

<h4>Background: </h4> Estimands are increasingly used in randomised trials to clarify research objectives. The ICH E9(R1) addendum sets out five attributes necessary to describe a well-defined estimand. However, the addendum was primarily developed for individually randomised trials. There is growing recognition that estimand descriptions for cluster randomised trials, where groups of individuals are randomised, m...

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Literature Corpus work
61d22142-d4f3-5736-84fa-788afdf337db
DOI
10.1101/2025.07.03.25330799
Open publication

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Development of a consensus extension of the estimands framework for cluster randomised trials (CRT-estimands): results from an international Delphi studyDOI 10.1101/2025.07.03.25330799
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