Article

<i>Fusobacterium nucleatum</i> outer membrane vesicles activate the TNFR1/NF-κB signaling pathway to promote OSCC proliferation

2025-11-03

Abstract excerpt

Fusobacterium nucleatum ( F. nucleatum, Fn) has emerged as a significant bacterium linked to cancer. However, the precise mechanisms by which Fn drives the progression of oral squamous cell carcinoma (OSCC) remain obscure. Outer membrane vesicles (OMVs), small vesicular structures secreted by Gram-negative bacteria, are known to contribute to their pathogenicity. This study investigated the role of Fn OMVs in ora...

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Literature Corpus work: aa1c5f41-0e4b-5c71-bdf2-02b7e2c578ed
DOI: 10.1101/2025.10.31.685796

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