Article

Molecular analysis and physical mapping of the human 3β-hydroxysteroid dehydrogenase δ5/δ4 isomerase gene family

1997-01-01

Abstract excerpt

3beta-hydroxysteroid dehydrogenase (3beta -HSD) catalyses the conversion of 3beta-hydroxy- Delta5-steroids into the corresponding Delta4-3-ketosteroids and is essential for the biosynthesis of mineralocorticoids, glucocorticoids and sex hormones. Two isoforms encoded by two highly homologous, closely linked 3beta-HSD genes (HSD3B1 and 2) are known to be expressed in humans. However, Southern blot analysis and 3B-H...

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Literature Corpus work: aa04b814-520f-5779-80a7-964de31b6adc
DOI: 10.5525/gla.thesis.71366

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