Article
Quantitative Method for the Analysis of Ivacaftor, Hydroxymethyl Ivacaftor, Ivacaftor Carboxylate, Lumacaftor, and Tezacaftor in Plasma and Sputum Using Liquid Chromatography With Tandem Mass Spectrometry and Its Clinical Applicability.
Therapeutic drug monitoring - 1 Aug 2021
Vonk Steffie E M, van der Meer-Vos Marloes, Bos Lieuwe D J, Neerincx Anne H, Majoor Christof J, Maitland-van der Zee Anke-Hilse, Mathôt Ron A A, Kemper E Marleen
Abstract excerpt
BACKGROUND: The novel cystic fibrosis transmembrane conductance regulator (CFTR) modulators, ivacaftor, lumacaftor, and tezacaftor, are the first drugs directly targeting the underlying pathophysiological mechanism in cystic fibrosis (CF); however, independent studies describing their pharmacokinetics are lacking. The aim of this study was to develop a quantification method for ivacaftor and its 2 main...
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