Article
Isotope dilution LC-MS/MS quantification of the cystic fibrosis transmembrane conductance regulator (CFTR) modulators ivacaftor, lumacaftor, tezacaftor, elexacaftor, and their major metabolites in human serum.
Clinical chemistry and laboratory medicine - 26 Jan 2022
Habler Katharina, Kalla Anne-Sophie, Rychlik Michael, Bruegel Mathias, Teupser Daniel, Nährig Susanne, Vogeser Michael, Paal Michael
Abstract excerpt
OBJECTIVES: Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulators have revolutionized the therapeutic landscape in CF treatment. These vital drugs are extensively metabolized via CYP3A, so caution must be exercised in multimodal CF therapy because of the risk of adverse drug interactions. Our goal was to develop a highly sensitive assay for the purpose of therapeutic drug monitoring (TDM) in...
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