Article

PKC Promotes T-Tubule Membrane Loss by Activating a PKD– NFκB Endocytic Pathway

2025-05-06

Abstract excerpt

<h4>Background</h4> In heart disease, the membrane of the cardiomyocyte transverse-axial tubular system (TATS) deteriorates. This impairs contractility, hinders recovery and predisposes to arrhythmia. However, the key signals and cellular processes driving TATS loss are not understood. We investigated protein kinase C (PKC) and its downstream signals in animal and human cardiomyocytes. <h4>Methods</h4> Ventricul...

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Literature Corpus work: a9cd19a5-ffd1-5b6f-8fe4-1e8225e33bb3
DOI: 10.1101/2025.05.04.651469

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