Article

Spatial Profiling of Lung SARS-CoV-2 and Influenza Virus Infection Dissects Virus-Specific Host Responses and Gene Signatures

2020-11-06

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged in late 2019 has spread globally, causing a pandemic of respiratory illness designated coronavirus disease 2019 (COVID-19). Robust blood biomarkers that reflect tissue damage are urgently needed to better stratify and triage infected patients. Here, we use spatial transcriptomics to generate an in-depth picture of the pulmonary transcrip...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a81a3e50-3f63-5877-a95b-65fbdf7b8879
DOI: 10.1101/2020.11.04.20225557

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial Profiling of Lung SARS-CoV-2 and Influenza Virus Infection Dissects Virus-Specific Host Responses and Gene SignaturesDOI 10.1101/2020.11.04.20225557Read

Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signaturesSemantic proximity Read

Spatial Mapping of SARS-CoV-2 and H1N1 Influenza Lung Injury Identifies Differential Transcriptional SignaturesSemantic proximity Read

Spatially resolved transcriptomics reveals distinct pulmonary immune responses during influenza virus and SARS-CoV-2 infectionsSemantic proximity Read

Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures.Semantic proximity Read

Gene expression profiling of SARS-CoV-2 infections reveal distinct primary lung cell and systemic immune infection responses that identify pathways relevant in COVID-19 diseaseSemantic proximity Read

Dual spatially resolved transcriptomics for SARS-CoV-2 host-pathogen colocalization studies in humansSemantic proximity Read

Cellular and molecular heterogeneities and signatures, and pathological trajectories of fatal COVID-19 lungs defined by spatial single-cell transcriptome analysisSemantic proximity Read

Transcriptomic profiling of cardiac tissues from SARS‐CoV ‐2 patients identifies DNA damageSemantic proximity Read

Comprehensive Transcriptomic Analysis of COVID-19 Blood, Lung, and AirwaySemantic proximity Read

Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary InfectionSemantic proximity Read

Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damageSemantic proximity Read

Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19Semantic proximity Read