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Article

Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures.

Cell reports. Medicine - 20 Apr 2021

Margaroli Camilla, Benson Paul, Sharma Nirmal S, Madison Matthew C, Robison Sarah W, Arora Nitin, Ton Kathy, Liang Yan, Zhang Liang, Patel Rakesh P, Gaggar Amit

Abstract excerpt

Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear whether ARDS from SARS-CoV-2 is similar to that observed in influenza H1N1, another common viral cause of lung injury. Here, we analyze specific ARDS regions of interest utilizing a spatial transcriptomic platform on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33778787
DOI: 10.1016/j.xcrm.2021.100242
PMCID: PMC7985929

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