Article

Elevated of HSP90 associates with expression of EGFR levels and predicts poor prognosis in non-small cell lung cancer patients

2022-10-07

Abstract excerpt

<h4>Background: </h4> The molecular chaperone protein HSP90 is a crucial mediator of proteostasis in eukaryotic cells under various stress conditions. EGFR participates in signal transduction relating to tumorigenesis and progression. The relationship between the combined expression of HSP90 and EGFR in non-small cell lung cancer (NSCLC) and clinicopathological features and long-term prognosis is not clear. Method...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a79c1696-8ea9-51d9-bcc0-b0353175c365
DOI: 10.21203/rs.3.rs-2101621/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elevated of HSP90 associates with expression of EGFR levels and predicts poor prognosis in non-small cell lung cancer patientsDOI 10.21203/rs.3.rs-2101621/v1Read

HSP90: A promising target for NSCLC treatments.Semantic proximity Read

HSP90 inhibitors in lung cancer: promise still unfulfilled.Semantic proximity Read

Inhibition of HSP90 in Driver Oncogene-Defined Lung Adenocarcinoma Cell Lines: Key Proteins Underpinning Therapeutic Efficacy.Semantic proximity Read

Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patientsSemantic proximity Read

High expression of HSP90 is associated with poor prognosis in patients with colorectal cancerSemantic proximity Read

The significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung cancer.Semantic proximity Read

eHSP90α in front-line therapy in EGFR exon 19 deletion and 21 Leu858Arg mutations in advanced lung adenocarcinoma.Semantic proximity Read

Hsp90 inhibition by WK88-1 potently suppresses the growth of gefitinib-resistant H1975 cells harboring the T790M mutation in EGFR.Semantic proximity Read

The E3 ubiquitin ligase CHIP selectively regulates mutant epidermal growth factor receptor by ubiquitination and degradation.Semantic proximity Read

EGFR-TKI-induced HSP70 degradation and BER suppression facilitate the occurrence of the EGFR T790 M resistant mutation in lung cancer cells.Semantic proximity Read

A Pan-Cancer Analysis of Heat-Shock Protein 90 Beta1(HSP90B1) in Human TumoursSemantic proximity Read

HSP70 Multi-Functionality in CancerSemantic proximity Read