Article

The perfect condition for the rising of superbugs: person-to-person contagion and antibiotic use are the key factors responsible for the positive correlation between antibiotic resistance gene diversity and virulence gene diversity in human metagenomes

2020-04-26

Abstract excerpt

1. This study aims to understand the cause of the recent observation that humans with a higher diversity of virulence genes in their metagenomes tend to be precisely those with higher diversity of antibiotic-resistance genes. We simulated the transferring of virulence and antibiotic-resistance genes in a community of interacting people where some take antibiotics. The diversities of the two genes types became posi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a77bb24a-b5e9-53f0-a621-216ddcc166f2
DOI: 10.1101/2020.04.25.061853

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The perfect condition for the rising of superbugs: person-to-person contagion and antibiotic use are the key factors responsible for the positive correlation between antibiotic resistance gene diversity and virulence gene diversity in human metagenomesDOI 10.1101/2020.04.25.061853Read

Metapopulation ecology links antibiotic resistance, consumption and patient transfers in a network of hospital wardsSemantic proximity Read

Host contact dynamics shapes richness and dominance of pathogen strainsSemantic proximity Read

VERA: agent-based modeling transmission of antibiotic resistance between human pathogens and gut microbiotaSemantic proximity Read

Universality of human microbial dynamicsSemantic proximity Read

Emergence of collective territorial defense in bacterial communities: horizontal gene transfer can stabilize microbiomes.Semantic proximity Read

Simulating multi-level dynamics of antimicrobial resistance in a membrane computing modelSemantic proximity Read

EVOLUTION O ANTIBIOTIC RESISTANCE BY HUMAN AND BACTERIAL NECHE CONSTRUCTIONSemantic proximity Read

Explaining the stable coexistence of drug-resistant and -susceptible pathogens: the resistance acquisition purifying selection model.Semantic proximity Read

COVID-19 lockdowns may reduce resistance genes diversity in the human microbiome and the need for antibioticsSemantic proximity Read

Are humans increasing bacterial evolvability?Semantic proximity Read

Quantifying the impact of treatment history on plasmid-mediated resistance evolution in human gut microbiotaSemantic proximity Read

Multilayer Networks of Plasmid Genetic Similarity Reveal Potential Pathways of Gene TransmissionSemantic proximity Read