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A primary microcephaly-associated sas-6 mutation perturbs centrosome duplication, dendrite morphogenesis, and ciliogenesis in Caenorhabditis elegans

2022-11-26

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The human SASS6(I62T) missense mutation has been linked with the incidence of primary microcephaly in a Pakistani family, although the mechanisms by which this mutation causes disease remain unclear. The SASS6(I62T) mutation corresponds to SAS-6(L69T) in C. elegans . Given that SAS-6 is highly conserved, we modeled this mutation in C. elegans and examined sas-6(L69T) effect on centrosome duplication, ciliogenes...

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Literature Corpus work: a71b10fc-520f-5843-985a-fdc305853dca
DOI: 10.1101/2022.11.25.518003

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A primary microcephaly-associated <i>sas-6</i> mutation perturbs centrosome duplication, dendrite morphogenesis, and ciliogenesis in <i>Caenorhabditis elegans</i>

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