Article

<i>IGHG4</i>Expression in C2 Human Dorsal Root Ganglion Potentially Links B Cells to Spreading Chronic Neck Pain

2024-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Very little is known about the molecular mechanisms underlying chronic neck pain, a highly prevalent and burdensome condition. We analyzed the C2 dorsal root ganglion (DRG) of patients with neck pain who underwent C1-2 arthrodesis surgery. Using spatial transcriptomics, we provide the first report of IGHG4 expression in a human DRG. IGHG4 encodes immunoglobulin G4 (IgG4). Infiltration of IgG4-pro...

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Literature Corpus work: a5d0fb0d-cc77-5bdd-a29d-fe2509142d0d
DOI: 10.1101/2024.11.12.24317004

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