Article

Redox-Driven Blood-Nerve Barrier Dysfunction in Diabetic Peripheral Neuropathy: Mechanisms and Therapeutic Opportunities

2026-05-12

Abstract excerpt

Diabetic peripheral neuropathy (DPN) remains a leading cause of disability in diabetes, yet current care is largely symptomatic. Increasing evidence places early dysfunction of the blood-nerve barrier (BNB)—a core element of the peripheral nerve neurovascular unit (PNVU)—at the intersection of metabolic stress and neuroinflammation. This review synthesizes a redox-centered model of BNB failure in DPN: (i) chronic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5c7a89e-cd81-5de2-ab6d-68f1b6982205
DOI: 10.20944/preprints202603.1003.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Redox-Driven Blood-Nerve Barrier Dysfunction in Diabetic Peripheral Neuropathy: Mechanisms and Therapeutic OpportunitiesDOI 10.20944/preprints202603.1003.v2Read

Mediators of diabetic neuropathy: is hyperglycemia the only culprit?Semantic proximity Read

The Role of Oxidative Stress in Peripheral Neuropathy.Semantic proximity Read

Diabetic neuropathy part 1: overview and symmetric phenotypes.Semantic proximity Read

Pathophysiology and treatment of painful diabetic neuropathy.Semantic proximity Read

Oxidative Stress, Neuroinflammation, and Microvascular Damage in Neurodegenerative Diseases: Mechanistic Insights and Therapeutic ApproachesSemantic proximity Read

The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive DeclineSemantic proximity Read

[Risk factors and onset mechanisms of diabetic neuropathy].Semantic proximity Read

Cellular and molecular mechanisms of endothelial dysfunction in diabetes.Semantic proximity Read

The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammationSemantic proximity Read

Mechanisms of Action for Diabetic Bladder Dysfunction — State of the ArtSemantic proximity Read

Endothelial Dysfunction in Diabetes Mellitus: New InsightsSemantic proximity Read

Macrophages protect against sensory axon degeneration in diabetic neuropathySemantic proximity Read