Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated

Abstract excerpt

<title>Abstract</title> <p>BACKGROUND. Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation. METHODS. DNA and RNA mutation status were assessed in 15 melanoma cell lines by Sanger sequencing and RNA-seq. We tested the cell lines responsiveness to BRAF inhibitors (vemu...

Topics

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• Cell Line, Tumor
• Drug Resistance, Neoplasm
• Melanoma
• Melanoma and MAPK Pathways
• Mutation
• Protein Kinase Inhibitors
• Proto-Oncogene Proteins B-raf
• Vemurafenib

Identifiers and source

Literature Corpus work

a5966f10-10cd-5974-a372-5d9fd2ab0464

DOI

10.21203/rs.3.rs-16973/v2