Article

Leveraging a large language model to predict protein phase transition: a physical, multiscale and interpretable approach

2023-11-22

Abstract excerpt

Protein phase transitions (PPTs) from the soluble state to a dense liquid phase (forming droplets via liquid-liquid phase separation) or to solid aggregates (such as amyloids) play key roles in pathological processes associated with age-related diseases such as Alzheimer’s disease. Several computational frameworks are capable of separately predicting the formation of droplets or amyloid aggregates based on protein...

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Literature Corpus work: a5833408-e443-5dfe-b3fc-b600fee6769f
DOI: 10.1101/2023.11.21.568125

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