Article

Human cortical pyramidal neurons: From spines to spikes via models

2018-02-19

Abstract excerpt

We present the first-ever detailed models of pyramidal cells from human neocortex, including models on their excitatory synapses, dendritic spines, dendritic NMDA- and somatic/axonal- Na + spikes that provided new insights into signal processing and computational capabilities of these principal cells. Six human layer 2 and layer 3 pyramidal cells (HL2/L3 PCs) were modeled, integrating detailed anatomical and phys...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a41d448-d8ac-50dc-8a22-5208219fe36f
DOI: 10.1101/267898

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human cortical pyramidal neurons: From spines to spikes via modelsDOI 10.1101/267898Read

High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neuronsSemantic proximity Read

A Minimal Biophysical Model of Neocortical Pyramidal Cells: Implications for Frontal Cortex Microcircuitry and Field Potential GenerationSemantic proximity Read

How to train your neuron: Developing a detailed, up-to-date, multipurpose model of hippocampal CA1 pyramidal cellsSemantic proximity Read

The Tripod neuron: a minimal structural reduction of the dendritic treeSemantic proximity Read

Higher synaptic threshold for NMDA spike generation in human neuronsSemantic proximity Read

Probing Action Potential Generation and Timing under Multiplexed Basal Dendritic Computations Using Two-photon 3D Holographic UncagingSemantic proximity Read

Human outperform mouse Purkinje cells in dendritic complexity and computational capacitySemantic proximity Read

Brain signal predictions from multi-scale networks using a linearized frameworkSemantic proximity Read

Cellular and Synaptic Diversity of Layer 2-3 Pyramidal Neurons in Human IndividualsSemantic proximity Read

<i>DendroTweaks</i> : An interactive approach for unraveling dendritic dynamicsSemantic proximity Read

Modeling reveals human-rodent differences in h-current kinetics influencing resonance in cortical layer 5 neuronsSemantic proximity Read

Weak electric fields promote resonance in neuronal spiking activity: analytical results from two-compartment cell and network modelsSemantic proximity Read