Article

Development of a quantitative metagenomic approach to establish quantitative limits and its application to viruses

2022-07-10

Abstract excerpt

<h4>ABSTRACT</h4> Quantitative metagenomic methods are maturing but continue to lack clearly-defined analytical limits. Here, we developed a computational tool, QuantMeta, to determine the absolute abundance of targets in metagenomes spiked with synthetic DNA standards. The tool establishes (1) entropy-based detection thresholds to confidently determine the presence of targets, and (2) an approach to identify and...

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Literature Corpus work: a4e884bd-5e23-5581-9a20-226ba7d692b1
DOI: 10.1101/2022.07.08.499345

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