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Development of a quantitative metagenomic approach to establish quantitative limits and its application to viruses

6 Feb 2025

Abstract excerpt

Quantitative metagenomic methods are maturing but continue to lack clearly-defined analytical limits. Here, we developed a computational tool, QuantMeta, to determine the absolute abundance of targets in metagenomes spiked with synthetic DNA standards. The tool establishes (i) entropy-based detection thresholds to confidently determine the presence of targets, and (ii) an approach to identify and correct read...

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PMID: 40036505
DOI: 10.1093/nar/gkaf118

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