Article

Mucosal host–microbe interactions associate with clinical phenotypes in inflammatory bowel disease

2022-06-04

Abstract excerpt

Dysregulation of gut mucosal host–microbe interactions is a central feature of inflammatory bowel disease (IBD). To study tissue-specific interactions, we performed transcriptomic (RNA-seq) and microbial (16S-rRNA-seq) profiling of 696 intestinal biopsies derived from 353 patients with IBD and controls. Analysis of transcript-bacteria interactions identified six distinct groups of inflammation-related pathways tha...

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Literature Corpus work: a3a74e86-648d-558e-9429-39902934ed5a
DOI: 10.1101/2022.06.04.494807

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