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Article

Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease.

Nature communications - 17 Feb 2024

Hu Shixian, Bourgonje Arno R, Gacesa Ranko, Jansen Bernadien H, Björk Johannes R, Bangma Amber, Hidding Iwan J, van Dullemen Hendrik M, Visschedijk Marijn C, Faber Klaas Nico, Dijkstra Gerard, Harmsen Hermie J M, Festen Eleonora A M, Vich Vila Arnau, Spekhorst Lieke M, Weersma Rinse K

Abstract excerpt

Disrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD. To study tissue-specific interactions, we perform transcriptomic (RNA-seq) and microbial (16S-rRNA-seq) profiling of 697 intestinal biopsies (645 derived from 335 patients with IBD and 52 from 16...

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Identifiers

PMID: 38368394
DOI: 10.1038/s41467-024-45855-2
PMCID: PMC10874382

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TNF

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