Back to search

Article

Bioinformatic identification of the potential afatinib drug resistance gene BIRC5 in non-small- cell lung cancer

2021-04-27

Abstract excerpt

<h4>Background: </h4> Drug resistance inevitably limits the efficacy of the second-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) afatinib, and the underlying causes of this resistance have not been determined. <h4>Methods: </h4> In this study, we demonstrated that baculovirus IAP repeat protein 5 (BIRC5) may confer afatinib resistance in non-small-cell lung cancer (NSCLC) via mul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a27d24b8-893a-5c61-ae7a-5a84c708127a
DOI
10.21203/rs.3.rs-396954/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Bioinformatic identification of the potential afatinib drug resistance gene BIRC5 in non-small- cell lung cancerDOI 10.21203/rs.3.rs-396954/v1
Prognostic Value of BIRC5 in Lung Adenocarcinoma Lacking EGFR, KRAS, and ALK Mutations by Integrated Bioinformatics AnalysisSemantic proximity
Knockdown of lncRNA BLACAT1 reverses the resistance of afatinib to non-small cell lung cancer via modulating STAT3 signallingSemantic proximity
Afatinib resistance in non-small cell lung cancer involves the PI3K/AKT and MAPK/ERK signalling pathways and epithelial-to-mesenchymal transition.Semantic proximity
Comprehensive analysis of BIRC5: from pan-cancer analysis to experimental validation.Semantic proximity
Integrative analysis of multi-omics data reveals inhibition of RB1 signaling promotes apatinib resistance of hepatocellular carcinomaSemantic proximity
An Integrative Analysis of the Putative Gefitinib-resistance Related Genes in a Lung Cancer Cell Line Model System.Semantic proximity
Polymorphism of Baculoviral Inhibitor of Apoptosis Repeat-Containing 5 (BIRC5) Can Be Associated with Clinical Outcome of Non-Small Cell Lung Cancer.Semantic proximity
A Novel KIF5B-EGFR Fusion Variant in Non-Small-Cell Lung Cancer and Response to Afatinib: A Case ReportSemantic proximity
Genetic correlation of crizotinib efficacy and resistance in ALK- rearranged non-small-cell lung cancer.Semantic proximity
Long Non-Coding RNA CRNDE is Involved in Resistance to EGFR Tyrosine Kinase Inhibitor in EGFR-Mutant Lung Cancer via eIF4A3/MUC1/EGFR SignalingSemantic proximity
Novel Resistance Mechanisms to Second-Generation EGFR Tyrosine Kinase Inhibitor Afatinib and Associations With Genomic Features in NSCLC.Semantic proximity
Genetic variation in a miR-335 binding site in BIRC5 alters susceptibility to lung cancer in Chinese Han populations.Semantic proximity
Select a neighboring publication to make it the new centre.