Article

Cross kingdom analysis of putative quadruplex-forming sequences in fungal genomes: novel antifungal targets to ameliorate fungal pathogenicity?

2020-09-23

Abstract excerpt

Fungi contribute to upwards of 1.5 million human deaths annually, are involved in the spoilage of up to a third of food crops, and have a devastating effect on plant and animal biodiversity. Moreover, this already significant issue is exacerbated by a rise in antifungal resistance and a critical requirement for novel drug targets. Quadruplexes are four-stranded secondary structures in nucleic acids which can regul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a205d748-cb13-593a-8e02-9700ac5b0000
DOI: 10.1101/2020.09.23.310581

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross kingdom analysis of putative quadruplex-forming sequences in fungal genomes: novel antifungal targets to ameliorate fungal pathogenicity?DOI 10.1101/2020.09.23.310581Read

The function and evolution of the Aspergillus genome.Semantic proximity Read

The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.Semantic proximity Read

Comparative pan-genomics reveals extensive variation in secondary metabolism and the non-coding repertoire of clinically-relevant Fusarium solani species complex membersSemantic proximity Read

Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus speciesSemantic proximity Read

Genetic Diversity of Human Fungal PathogensSemantic proximity Read

Uncovering the role of mitochondrial genome in pathogenicity and drug resistance in pathogenic fungiSemantic proximity Read

Co-evolution of Large inverted repeats and G-quadruplex DNA in fungal mitochondria may facilitate mitogenome stability: the case of MalasseziaSemantic proximity Read

Essential Gene Discovery in the Basidiomycete Cryptococcus neoformans for Antifungal Drug Target PrioritizationSemantic proximity Read

Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogensSemantic proximity Read

Identification and Targeting Putative G-Quadruplex Sequences in Candida glabrata : A Route to Virulence and Pathogenesis Control?Semantic proximity Read

Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatusSemantic proximity Read

Unraveling the genomic diversity and virulence of human fungal pathogens through pangenomics.Semantic proximity Read