From Coexpression to Causality: Defining Functional Hub Genes in Basal-like Breast Cancer Networks

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> The behaviour of complex biological systems emerges from the coordinated activity of networked molecular components. In this context, gene regulatory networks (aka gene coexpression networks) offer insights into the regulation of gene expression programs. In cancer, aberrant gene expression underlies molecular and clinical features, and identifying key networked...

Topics

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• Bioinformatics and Genomic Networks
• Breast Cancer Treatment Studies
• Cancer Cells and Metastasis
• Ferroptosis and cancer prognosis
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic
• Gene Ontology
• Gene Regulatory Networks

Identifiers and source

Literature Corpus work

a1f52759-efd3-509b-b2f8-a693a3020c0f

DOI

10.21203/rs.3.rs-7321266/v1