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Sharp Downregulation of Hub Genes Associated With the Pathogenesis of Breast Cancer From Ductal Carcinoma In Situ to Invasive Ductal Carcinoma

21 May 2021

Abstract excerpt

Introduction Breast atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) are precursor stages of invasive ductal carcinoma (IDC). This study aimed to investigate the pathogenesis of breast cancer by dynamically analyzing expression changes of hub genes from normal mammary epithelium (NME) to simple ductal hyperplasia (SH), ADH, DCIS, and finally to IDC. Methods Laser-capture microdissection (LCM)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34094915
DOI: 10.3389/fonc.2021.634569

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