Article

Pubertal maturation and chemotherapy-associated disruption of the pediatric ovary revealed by multimodal single-cell profiling

2026-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Ovarian tissue cryopreservation enables fertility preservation in females undergoing gonadotoxic therapies, restoring fertility in adults. Although offered even before puberty, the childhood ovary and its vulnerability to therapy remain poorly characterized. Here, ovarian tissue from 16 patients undergoing fertility preservation (aged 1-16 years) and 11 adult controls (aged 22-32 years) was anal...

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Literature Corpus work: a1ccda81-b6a7-5d40-83da-997f531ae527
DOI: 10.64898/2026.06.03.729786

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