Immune cell-mediated CETP gene and the causal relationship with ischemic stroke disease risk: Mendelian randomization analysis with mediation effect assessment

Abstract excerpt

<title>Abstract</title> <p>Background: The advancement of cholesterol ester transfer protein inhibitors in the treatment of coronary heart disease (CHD) has thus far failed to produce approved therapeutic agents, despite Mendelian randomization (MR) studies establishing CETP gene as a viable target for CHD prevention. However, there is currently no empirical evidence supporting the role of CETP-related genes as...

Topics

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• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Ischemic Stroke
• Mendelian Randomization Analysis
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Factors
• Stroke

Identifiers and source

Literature Corpus work

a18678e1-ed97-5ece-81d3-fce07ab21060

DOI

10.21203/rs.3.rs-5648796/v1