A Developmental Mechanism Linking Heart Evolution and Congenital Defects

Abstract excerpt

The evolution of double circulation in vertebrates required precise remodeling of the embryonic outflow tract (OFT), but the mechanisms enabling this transition remain unclear. Here, we show that oxygen acts as a developmental switch regulating apoptosis during OFT septation. In chick embryos, transient hypoxia disrupts apoptosis and produces atavistic phenotypes resembling ancestral vertebrate hearts with a singl...

Topics

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• Adaptation, Physiological
• Biomedical Research
• Cancer, Hypoxia, and Metabolism
• Congenital heart defects research
• Congenital Heart Disease Studies
• Coronary Artery Anomalies
• High Altitude and Hypoxia
• Pregnancy and preeclampsia studies

Identifiers and source

Literature Corpus work

a13e2b1f-5e25-5457-a494-f5dc576bdf4a

DOI

10.1101/2025.05.20.655032