Article

Perturbation of ACE2 structural ensembles by SARS-CoV-2 spike protein binding

2021-03-02

Abstract excerpt

The human ACE2 enzyme serves as a critical first recognition point of coronaviruses, including SARS-CoV-2. In particular, the extracellular domain of ACE2 interacts directly with the S1 tailspike protein of the SARS-CoV-2 virion through a broad protein-protein interface. Although this interaction has been characterized by X-ray crystallography and Cryo-EM, these structures do not reveal significant differences in...

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Literature Corpus work: a0ccd3e7-76c1-5715-ba00-a58c6a41fa1c
DOI: 10.1101/2021.03.02.433608

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